International Review of Ophthalmology ›› 2020, Vol. 44 ›› Issue (5): 318-323.doi: 10.3760/ cma.j.issn.1673-5803.2020.05.005

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New progress of ocular signal transduction in the pathogenesis of myopia

Xu Yushan, Zhang Fengju   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing  Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China
  • Received:2020-02-25 Online:2020-10-22 Published:2020-11-01
  • Contact: Zhang Fengju, Email: wxw93@hotmail.com
  • Supported by:

     

    National Natural Science Foundation of China (81570877)；High Level Talent Fund of the Beijing Health Care (2013-2-023); Beijing Economic and Technological Development Zone New Innovation Project Leading Talent Training Fund（20180509）

Abstract: With the increasing prevalence of myopia in China, many studies have been done to explore the pathogenesis of myopia to prevent and treat myopia effectively. Previous studies have shown that the abnormal visual stimulation of myopia is detected by retinal neurons, which generates signals through RPE and choroid into sclera, resulting in scleral remodeling and axial elongation. However, it is not clear how signals are transducted from retina to sclera. Studies have found that TGF-β/Smad, JAK/STAT, retinoic acid, PPAR, Wnt/β-catenin, dopamine, acetylcholine receptor and GABA signaling pathways play an important role in transduction, the study of which has significant clinical value in the prevention and treatment of myopia. (Int Rev Ophthalmol, 2020, 44：  318-323)

Key words: myopia, signal transduction